Focused on the development of a new generation of novel, broad-spectrum pharmaceuticals for the warfighter, astronaut, veteran, first responder, and civilian
Motion & Space Sickness
Depression & Post-Traumatic Stress Disorder
Traumatic Brain Injury
Defender Pharmaceuticals, Inc.
Defender Pharmacuticals, Inc. (DPI) is a development-stage pharmaceutical organization focused on the discovery, development, and partnering of anti-emetic (anti-vomiting and anti-nausea) compounds for both the human and veterinary markets.
The primary focus of DPI is the development of scopolamine as a motion sickness countermeasure, specifically in the military and for astronauts, filling a large unmet need for an easily-administered, fast-acting motion sickness remedy, and can lead to life-threatening and mission-threatening debilitation.
The effectiveness of scopolamine has also been shown for the treatment of depression, PTSD, and as a chemical defense.
Lead Development Compound: Scopolamine
Primary Indication: Motion Sickness
Our lead product, INSCOP, is an NDA-stage product, meaning that all pre-clinical and clinical studies have been completed successfully, including two well-designed placebo-controlled phase 3 studies which showed highly-statistically significant efficacy for both treatment of motion sickness and prevention of motion sickness.
transdermally delivered scopolamine, with few, if any, side-effects.
Our formulation, "INSCOP" intranasal gel, has been shown to work much faster and more reliably than transdermal delivery with few if any side effects.
Other uses of scopolamine include treatment of postoperative nausea
Historically, scopolamine has been administered orally, subcutaneously, topically (for pupillary dilation), intramuscularly, intravenously, and via transdermal patch. Most methods are limited by side effects or issues with efficacy and/or half-life; however, INSCOP intranasal gel, with its precise dosing, has been shown to work faster and more reliably than
and vomiting and gastrointestinal (GI), renal, or biliary spasm; irritable bowel syndrome; clozapine-induced hypersalivation; and bowel colic. It is used as an anesthetic preceding GI radiology and endoscopy and can provide central nervous system protection against chemical warfare agents as well as robust antidepressant effects in patients with major depressive disorder and depression.